Drogo is a powerful warlord and feared warrior.(known as the Great Khal) He marries Daenerys Targaryen and subsequently grows to love her. He promises to retake the Seven Kingdoms for her after she survives an assassination attempt. He raids a Lhazareen village to take slaves to fund the planned invasion. After the fight was over he was challenged to a fight by the Khal of the men in the village who believed him unworthy to continue leading the Khalasar as it appeared the Khal was obeying the orders of a woman. Drogo kills the warrior but receives a scratch to his chest and is treated by the godswife and maegi Mirri Maz Duur. His wound festers and he becomes gravely unwell. Daenerys asks Mirri Maz Duur to save him using blood magic but Mirri Maz Duur uses a spell that leaves him in a vegetative state in revenge for the destruction of her village. Daenerys ends his suffering by smothering him, then burning the body. Daenerys walks into the flames with her dragon eggs, but survives the inferno and hatches three dragons, and names the large black one after him.

Drogo is a khal or warlord of the Dothraki, the famed nomadic horse-lords of the eastern continent beyond the Narrow Sea. The Dothraki are fierce warriors, skilled in battle, unrelenting in combat and known for savagery towards non-Dothraki.