A class of oral medicine for type 2 diabetes that lowers blood glucose by helping the pancreas make more insulin and by helping the body better use the insulin it makes. (generic names/brand names: chlorpropamide/diabinese; glimepiride/amaryl; glipizide/glucotrol, glucotrol xl; glyburide/diabeta, glynase prestab, micronase; tolazamide (generic only); tolbutamide (generic only). )