Stage II prostate cancer is divided into stages IIA and IIB. In stage IIA, cancer is found (1) by needle biopsy or in a small amount of tissue during surgery for other reasons; the prostate-specific antigen (PSA) level is lower than 20 and the Gleason score is 7; or (2) by needle biopsy or in a small amount of tissue during surgery for other reasons; the PSA level is at least 10 but lower than 20 and the Gleason score is 6 or lower; or (3) in one-half or less of one lobe of the prostate; the PSA level is at least 10 but lower than 20 and the Gleason score is 6 or lower; or (4) in one-half or less of one lobe of the prostate; the PSA level is lower than 20 and the Gleason score is 7; or (5) in more than one-half of one lobe of the prostate; the PSA level is lower than 20 and the Gleason score is 7 or lower; or (6) in more than one-half of one lobe of the prostate, and the PSA level and Gleason score are not known. In stage IIB, cancer (1) is found in both lobes of the prostate; the PSA can be any level and the Gleason score can range from 2 to 10; or (2) cannot be felt during a digital rectal exam and is not visible by imaging, and the tumor has not spread outside the prostate; the PSA level is 20 or higher and the Gleason score can range from 2 to 10; or (3) cannot be felt during a digital rectal exam and is not visible by imaging, and the tumor has not spread outside the prostate; the PSA can be any level and the Gleason score is 8 or higher.