Stage II gallbladder cancer is divided into stages IIA and IIB. In stage IIB, cancer has spread in one of the following ways: (1) beyond the innermost layer to the connective tissue and to nearby lymph nodes; or (2) to the muscle layer and nearby lymph nodes; or (3) beyond the muscle layer to the connective tissue around the muscle and nearby lymph nodes; or (4) through the tissue that covers the gallbladder and/or to the liver and/or to one nearby organ, such as the stomach, small intestine, colon, pancreas, or bile ducts outside the liver, and to nearby lymph nodes.