The layer of ozone that begins approximately 15 km above Earth and thins to an almost negligible amount at about 50 km, shields the Earth from harmful ultraviolet radiation from the sun. The highest natural concentration of ozone (approximately 10 parts per million by volume) occurs in the stratosphere at approximately 25 km above Earth. The stratospheric ozone concentration changes throughout the year as stratospheric circulation changes with the seasons. Natural events such as volcanoes and solar flares can produce changes in ozone concentration, but man-made changes are of the greatest concern.