A lymphophenic form of congenital immunologic deficiency and thymic hypoplasia which was first described by Glanzmann and Riniker in 1950. Subsequent detailed clinical, pathologic, and immunologic studies of siblings of each of the original two cases demonstrated the familial nature of this disorder and the associated defect of agammaglobulinemia. Since the Swiss investigators have contributed heavily to the definition of this autosomal recessive disease, it is frequently referred to as the "Swiss type" agammaglobulinemia.