Introduced onto the market by pharmaceutical giant Eli Lilly in 1988, Prozac (Fluoxetine) is taken to combat depression experienced by as many as 17 million Americans. The first of many such antidepressants (selective serotonin re-uptake inhibitors, or SSRIs), Prozac is now the brand name that is generally used to refer to current medical responses to chemically induced depression, though doctors often choose to prescribe Zoloft instead. Many doctors believe that depression may be caused by a chemical imbalance of serotonin, which a daily capsule of fluoxetine can correct with few side-effects, though the drug’s safety has been brought into question recently. Often considered the wonder drug of the early 1990s, Prozac has received widespread attention, from medical practice to humor.