The Mercedes-Benz S-Class is a series of luxury sedans produced by German automaker Mercedes-Benz, a division of German company Daimler AG. The classification was officially introduced in 1972 with the W116 S-Class, which succeeded previous Mercedes-Benz models dating to the mid-1950s.

The S-Class has served as the flagship model for Mercedes for over fifty years in its various incarnations. The S-Class has debuted many of the company's latest innovations, including drivetrain technologies, interior features, and safety systems (such as the first seatbelt pretensioners).

The S-Class has ranked as the world's best-selling luxury sedan, and its latest generation, the W222 S-Class, premiered in 2013. As in previous iterations, the W221 S-Class is sold in standard- and long-wheelbase versions; I4, V6, V8, V12, diesel and hybrid powertrains are offered. All models built in Mexico or sold in the United States are only available in long wheelbase.