Cannabis dependence is defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as a condition requiring treatment.

Cannabis is one of the most widely used drugs in the world with a dependance rate between 9% and 10% in adult users. In the US, as of 2013 cannabis is the substance most commonly identified used by people admitted to treatment facilities. Demand for treatment for cannabis use disorder increased internationally between 1995 and 2002.