The Boeing 777-Freighter is an all-cargo version of the twin-engine jet modeled after the 777-200LR Worldliner (Longer Range) passenger airplane. It shares many of the 200LR construction features such as the airframe, engines, and fuel capacity. With a maximum payload of 226,000 lb (103,000 kg), the 777-Freighter's cargo capacity is similar to the 243,000 lb (110,000 kg) of the 747-200F. The 777-Freighter can fly up to 4,900 nautical miles (9,070 km) at maximum payload, a range that is longer than any other freighters, delivering improved operating economics on a twin-engine jet. The freighter also shares the 777 Family's flight deck, fly-by-wire design and an advanced wing design, including raked wing tips. The 777-Freighter is powered by General Electric's GE90-110B1L commercial jet engine.

The 777-Freighter is designed to integrate smoothly with existing cargo operations and facilitate interlining with 747 freighter fleets. Cargo operators can transfer 10-foot-high pallets between the two models via the large main deck cargo door.