Agrafa is a mountainous region in Evrytania and Karditsa regional units in mainland Greece, consisting mainly of small villages. It is the southernmost part of the Pindus range. There is also a municipality with the same name, the Municipality of Agrafa, but it covers only a small percentage of the area.

The Agrafa region is famous for its complete autonomy throughout the entire 400 years of Ottoman Turkish occupation of Greece. The word agrafa literally translates to "unwritten" or uncharted; because the Ottomans were unable to conquer this region, the area and its population were not recorded in the Sultan's tax register. As a result the people were usually free to conduct their business and customs as they pleased without Ottoman influence.